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outcomes. We explored heterogeneity using a 2 test and measured the quantity of heterogeneity with the I2 statistic.16 We used random effects models to summarise relative risk and absolute risk reduction estimates.17 Analyses were performed in RevMan version 5.2 (Cochrane Collaboration, 2013). All P values are two tailed. Where the pooled estimates of relative risk were statistically significant we calculated the numbers needed to treat (NNT) for all outcomes. The study is reported according to the PRISMA checklist.18
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